Tau Proteins, Antibodies, cDNA Clones Research Reagents

MAPT (Microtubule Associated Protein Tau, also known as TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103), located on 17q21.31, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 78928 Da protein composed of 758 amino acids. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. Diseases such as Frontotemporal Dementia and Supranuclear Palsy, Progressive, 1 are associated with MAPT. The related pathways of MAPT include Neuroscience and Development Slit-Robo signaling.

Tau Protein (1)

    Tau Antibody (2)

      Tau cDNA Clone (35)

      NM_016841.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001123066.3

      In expression vector

      NM_001123067.3

      In expression vector

      NM_016835.4

      In expression vector

      NM_010838.4

      克隆载体 cDNA 产品

      In lentiviral vector

      MGI:97180

      In expression vector

      Tau qPCR Primer (1)

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      Tau 分子背景

      MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

      Tau 参考文献

      • Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91.
      • Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62.
      • Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26.

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