TCF4/E2-2 Antibodies, cDNA Clones Research Reagents

TCF4 (Transcription Factor 4, also known as E2-2; ITF2; PTHS; SEF2; CDG2T; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19), located on 18q21.2, is a Protein Coding gene. The gene produces a 71308 Da protein composed of 667 amino acids. This gene encodes transcription factor 4. TCF4 is a broadly expressed basic helix-loop-helix (bHLH) protein that functions as a homodimer or as a heterodimer with other bHLH proteins. Diseases such as Pitt-Hopkins Syndrome and Corneal Dystrophy, Fuchs Endothelial, 3 are associated with TCF4.

TCF4/E2-2 Antibody (1)

    TCF4/E2-2 cDNA Clone (15)

    NM_003199

    克隆载体 cDNA 产品

    In lentiviral vector

    TCF4/E2-2 qPCR Primer (1)

    TCF4/E2-2 分子背景

    Transcription factor 7 like 2 (TCF7L2, also known as TCF4) is a Wnt signaling pathway transcription factor involved in the regulation of numerous Wnt targeted genes. TCF4 is critical in the vertebrate intestinal epithelium, where TCF4-β-catenin complexes are necessary for the maintenance of a proliferative compartment, and their abnormal formation initiates tumorigenesis. β-catenin, an upstream protein of TCF4, accumulates in the cytoplasm, then translocates to the nucleus to activate the β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional machinery and regulates target genes. Previous studies showed that TCF4 was involved in cell proliferation and apoptosis. Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language impairment and development delay.

    TCF4/E2-2 参考文献

    • Liu X, et al. (2016) T-cell factor (tcf/lef1) binding elements (tbes) of fasl (fas ligand or cd95 ligand) bind and cluster fas (cd95) and form complexes with the tcf-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation. Cell Mol Neurobiol 36 (6): 1001-1013.
    • Lan F, et al. (2012) Genome-wide identification of tcf7l2/tcf4 target mirnas reveals a role for mir-21 in wnt-driven epithelial cancer. Int J Oncol 40 (2): 519-526.
    • Kennedy AJ, et al. (2016) Tcf4 regulates synaptic plasticity, DNA methylation, and memory function. Cell Rep 16 (10): 2666-2685.
    • Costa AM, et al. (2013) Grg5/aes interacts with t-cell factor 4 (tcf4) and downregulates wnt signaling in human cells and zebrafish embryos. PLoS One 8 (7): e67694.

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