TEM7 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PLXDC1 (Plexin Domain Containing 1) is a protein coding gene located on human chromosome 17q12. PLXDC1 is also known as TEM3 and TEM7. The human PLXDC1 gene encodes a 55760 Da protein containing 500 amino acids. The PLXDC1 protein is ubiquitously expressed in gall bladder, endometrium and other tissues. PLXDC2 is an important paralog of PLXDC1 gene. PLXDC1 is associated with some diseases, including Mulchandani-Bhoj-Conlin Syndrome.

TEM7 Protein (1)

    TEM7 Antibody (9)

      TEM7 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      TEM7 cDNA Clone (13)

      XM_005583997.1

      克隆载体 cDNA 产品

      In lentiviral vector

      TEM7 Lysate (1)

        TEM7 分子背景

        Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. PLXDC1 / TEM3 is not detectable in endothelial cells from normal tissue. PLXDC1 / TEM3 plays a critical role in endothelial cell capillary morphogenesis. PLXDC1 / TEM3 may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). PLXDC1 / TEM3 may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (PDR). PLXDC1 / TEM3 interacts with NID1. It may also interact with CTTN.

        TEM7 参考文献

        • Beaty,R.M. et al., 2007,J Neurooncol. 81 (3):241-8.
        • Miller,S.F. et al., 2007, Gene Expr Patterns. 7 (5):635-44.
        • Yamaji,Y. et al., 2008, Invest Ophthalmol Vis Sci. 49 (7):3151-7.

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