TFF3 Proteins, cDNA Clones Research Reagents

TFF3 (Trefoil Factor 3) is a protein coding gene located on human chromosome 21q22.3. TFF3 is also known as ITF, P1B and TFI. The human TFF3 gene encodes a 10181 Da protein containing 94 amino acids. The TFF3 protein is biasedly expressed in colon, thyroid and other tissues. Among its related pathways are IL4-mediated signaling events and HIF-1-alpha transcription factor network. TFF1 is an important paralog of TFF3 gene. TFF3 is associated with some diseases, including Middle Cranial Fossa Meningioma and Facial Nerve Neoplasm.

TFF3 Protein (1)

    TFF3 cDNA Clone (2)


    In expression vector

    In lentiviral vector

    TFF3 Lysate (1)


      TFF3 分子背景

      Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, and apoptosis might be associated with specific embryonic epithelial cells. TFF3 peptide may also be considered as a marker for mucosal maturation. Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The involvement of TFF3 in the pathogenesis of rhonchopathy and OSA and lead to the hypothesis that reduction of TFF3 production by the epithelium and subepithelial mucous glands of the uvula contributes to an increase in breathing resistance due to a change in mucus organization.

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