TGFBR3 Proteins, Antibodies, cDNA Clones Research Reagents

TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a protein coding gene located on human chromosome 1p22.1. TGFBR3 is also known as BGCAN and betaglycan. The human TGFBR3 gene encodes a 93499 Da protein containing 851 amino acids. The TGFBR3 protein is ubiquitously expressed in fat, ovary and other tissues. Among its related pathways are Cell adhesion_Plasmin signaling and Apoptotic Pathways in Synovial Fibroblasts. TGFBR3 is related to heparin binding and SMAD binding. ENG is an important paralog of TGFBR3 gene. TGFBR3 is associated with some diseases, including Familial Cerebral Saccular Aneurysm and Priapism.

TGFBR3 Protein (2)

    TGFBR3 Antibody (3)

      TGFBR3 cDNA Clone (26)

      NM_003243.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011578.2

      克隆载体 cDNA 产品

      In lentiviral vector

      TGFBR3 Lysate (2)

        TGFBR3 分子背景

        Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

        TGFBR3 参考文献

        • Johnson DW, et al. (1996) Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7.
        • Rotzer D, et al. (2001) Type III TGF-beta receptor-independent signalling of TGF-beta2 via T betaRII-B, an alternatively spliced TGF- type II receptor. EMBO J. 20 (3): 480-90.
        • Gao J, et al. (1999) Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22.

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