THSD1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

THSD1 (Thrombospondin Type 1 Domain Containing 1) is a protein coding gene located on human chromosome 13q14.3. THSD1 is also known as TMTSP, ANIB12 and UNQ3010. The human THSD1 gene encodes a 94584 Da protein containing 852 amino acids. The THSD1 protein is broadly expressed in lung, placenta and other tissues. Among its related pathways are Metabolism of proteins and O-glycosylation of TSR domain-containing proteins. THSD1 is associated with some diseases, including Aneurysm, Intracranial Berry, 12 and Familial Cerebral Saccular Aneurysm.

THSD1 Protein (1)

    THSD1 Antibody (5)

      THSD1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      THSD1 cDNA Clone (16)

      NM_018676.3

      In expression vector

      NM_019576.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001108878.1

      克隆载体 cDNA 产品

      In lentiviral vector

      THSD1 qPCR Primer (1)

      THSD1 Lysate (1)

        THSD1 分子背景

        Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein that contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

        THSD1 参考文献

        • Lawler J. (2002) Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 6(1): 1-12.
        • Ren B, et al. (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 1765(2): 178-88.
        • Mirochnik Y, et al. (2008) Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr Drug Targets. 9(10): 851-62.
        • Bonnefoy A, et al. (2008) The evolving role of thrombospondin-1 in hemostasis and vascular biology. Cell Mol Life Sci. 65(5): 713-27.
        • Isenberg JS, et al. (2008) Thrombospondin-1: a physiological regulator of nitric oxide signaling. Cell Mol Life Sci. 65(5): 728-42.

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