THSD1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

THSD1 (Thrombospondin Type 1 Domain Containing 1) is a protein coding gene located on human chromosome 13q14.3. THSD1 is also known as TMTSP, ANIB12 and UNQ3010. The human THSD1 gene encodes a 94584 Da protein containing 852 amino acids. The THSD1 protein is broadly expressed in lung, placenta and other tissues. Among its related pathways are Metabolism of proteins and O-glycosylation of TSR domain-containing proteins. THSD1 is associated with some diseases, including Aneurysm, Intracranial Berry, 12 and Familial Cerebral Saccular Aneurysm.

THSD1 Protein (1)

    THSD1 Antibody (5)

      THSD1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      THSD1 cDNA Clone (16)


      In expression vector


      克隆载体 cDNA 产品

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      THSD1 qPCR Primer (1)

      THSD1 Lysate (1)

        THSD1 分子背景

        Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein that contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. In vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types.

        THSD1 参考文献

        • Lawler J. (2002) Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 6(1): 1-12.
        • Ren B, et al. (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 1765(2): 178-88.
        • Mirochnik Y, et al. (2008) Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr Drug Targets. 9(10): 851-62.
        • Bonnefoy A, et al. (2008) The evolving role of thrombospondin-1 in hemostasis and vascular biology. Cell Mol Life Sci. 65(5): 713-27.
        • Isenberg JS, et al. (2008) Thrombospondin-1: a physiological regulator of nitric oxide signaling. Cell Mol Life Sci. 65(5): 728-42.

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