Tie-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a protein coding gene located on human chromosome 1p34.2. TIE1 is also known as TIE and JTK14. The human TIE1 gene encodes a 125090 Da protein containing 1138 amino acids. The TIE1 protein is broadly expressed in placenta, fat and other tissues. Among its related pathways are Immune response IL-23 signaling pathway and Activation of cAMP-Dependent PKA. TIE1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. TEK is an important paralog of TIE1 gene. TIE1 is associated with some diseases, including Angiosarcoma and Arteriovenous Malformation.

Tie-1 Protein (1)

    Tie-1 Antibody (6)

      Tie-1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      Tie-1 cDNA Clone (13)

      NM_005424.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Tie-1 qPCR Primer (1)

      Tie-1 Lysate (1)

        更多受客户欢迎的产品

        Tie-1 分子背景

        Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little to no activity. Embryos deficient in Tie1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. Tie1 is significantly higher in human aortic endothelial cells than in human umbilical vein endothelial cells. Additionally, attachment of cells of monocytic lineage to endothelial cells is also enhanced by Tie1 expression. Collectively Tie1 has a proinflammatory property and may play a role in endothelial inflammatory diseases such as atherosclerosis.

        Tie-1 参考文献

        • Chan B, et al. (2008) Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 371(3): 475-9.
        • Sato TN, et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 376(6535): 70-4.
        • Rees KA, et al. (2007) The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol. 31(4): 893-7.
        • Kontos CD, et al. (2002) The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 22(6): 1704-13.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.