TNFR2/TNFRSF1B Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF1B (TNF Receptor Superfamily Member 1B) is a protein coding gene located on human chromosome 1p36.22. TNFRSF1B is also known as p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR and TNF-R-II. The human TNFRSF1B gene encodes a 48291 Da protein containing 461 amino acids. The TNFRSF1B protein is broadly expressed in appendix, spleen and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and NF-KappaB Family Pathway. TNFRSF1B is related to ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. TNFRSF11A is an important paralog of TNFRSF1B gene. TNFRSF1B is associated with some diseases, including Mycosis Fungoides and Sezary's Disease.

All TNFR2/TNFRSF1B Reagents

TNFR2/TNFRSF1B Protein (8)

TNFR2/TNFRSF1B Antibody (20)

    TNFR2/TNFRSF1B ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

    TNFR2/TNFRSF1B cDNA Clone (41)

    NM_001066.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_011610.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_130426.4T

    In expression vector

    In lentiviral vector

    XM_001105753.2

    克隆载体 cDNA 产品

    In lentiviral vector

    TNFR2/TNFRSF1B Lysate (7)

      TNFR2/TNFRSF1B 分子背景

      Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

      TNFR2/TNFRSF1B 参考文献

      • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
      • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
      • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.

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