TNFRSF1A Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF1A (TNF Receptor Superfamily Member 1A) is a protein coding gene located on human chromosome 12p13.31. TNFRSF1A is also known as FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I and TNF-R55. The human TNFRSF1A gene encodes a 50495 Da protein containing 455 amino acids. The TNFRSF1A protein is ubiquitously expressed in small intestine, gall bladder and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Signal transduction_JNK pathway. TNFRSF1A is related to tumor necrosis factor-activated receptor activity. TNFRSF25 is an important paralog of TNFRSF1A gene. TNFRSF1A is associated with some diseases, including Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5.

TNFRSF1A Protein (7)

    TNFRSF1A Antibody (19)

      TNFRSF1A ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

      TNFRSF1A cDNA Clone (52)

      NM_001065.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011609.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_013091.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001118232.2

      克隆载体 cDNA 产品

      In lentiviral vector

      TNFRSF1A Lysate (7)

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        TNFRSF1A 分子背景

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD120a (cluste of differentiation 120a), also known as TNFR1 / TNFRSF1A, is a member of CD family, tumor necrosis factor receptor superfamily. CD120a is one of the most primary receptors for the tumor necrosis factor-alpha. It has been shown to be localized to both plasma membrane lipid rafts and the trans golgi complex with the help of the death domain (DD). CD120a can activate the transcription factor NF-κB, mediate apoptosis, and regulate inflammation processes.

        TNFRSF1A 参考文献

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Cottin V, et al. (2002) Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain. The journal of immunology. 168: 4095-102.

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