Transglutaminase 2/TGM2 Proteins, Antibodies, cDNA Clones Research Reagents

TGM2 (Transglutaminase 2) is a protein coding gene located on human chromosome 20q11.23. TGM2 is also known as TGC and TG(C). The human TGM2 gene encodes a 77329 Da protein containing 687 amino acids. The TGM2 protein is broadly expressed in placenta, endometrium and other tissues. Among its related pathways are Parkinson disease and Ca, cAMP and Lipid Signaling. TGM2 is related to GTP binding and protein-glutamine gamma-glutamyltransferase activity. TGM5 is an important paralog of TGM2 gene. TGM2 is associated with some diseases, including Dermatitis Herpetiformis and Balanitis Xerotica Obliterans.

Transglutaminase 2/TGM2 Protein (1)

    Transglutaminase 2/TGM2 Antibody (3)

      Transglutaminase 2/TGM2 cDNA Clone (45)

      NM_004613.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_009373.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019386.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Transglutaminase 2/TGM2 Lysate (1)

        Transglutaminase 2/TGM2 分子背景

        Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.

        Transglutaminase 2/TGM2 参考文献

        • Ruan Q, et al. (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci. 12: 891-904.
        • Ai L, et al. (2008) The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis. 29(3): 510-8.
        • Filiano AJ, et al. (2010) Transglutaminase 2 protects against ischemic stroke. Neurobiol Dis. 39(3): 334-43.
        • Park D, et al. (2010) Transglutaminase 2: a multi-functional protein in multiple subcellular compartments. Amino Acids. 39(3): 619-31.
        • Miyoshi N, et al. (2010) TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. Ann Surg Oncol. 17(4): 967-72.

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