TREM-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a protein coding gene located on human chromosome 6p21.1. TREM1 is also known as CD354 and TREM-1. The human TREM1 gene encodes a 26387 Da protein containing 234 amino acids. The TREM1 protein is biasedly expressed in bone marrow, appendix and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. TREM1 is related to scaffold protein binding. TREM1 is associated with some diseases, including Suppurative Cholangitis and Acute Cholangitis.

TREM-1 Protein (3)

    TREM-1 Antibody (9)

      TREM-1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      TREM-1 cDNA Clone (26)

      NM_018643.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_004739942.1

      克隆载体 cDNA 产品

      In lentiviral vector

      TREM-1 qPCR Primer (1)

      TREM-1 Lysate (3)

        TREM-1 分子背景

        TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.

        TREM-1 参考文献

        • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
        • Bouchon, A. et al., 2001, Nature. 410: 1103-1107.
        • Bleharski, J.R. et al., 2003, J. Immunol. 170: 3812-3818.

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