TRP1 Proteins, Antibodies, cDNA Clones Research Reagents

TYRP1 (Tyrosinase Related Protein 1) is a protein coding gene located on human chromosome 9p23. TYRP1 is also known as TRP, CAS2, CATB, GP75, OCA3, TRP1, TYRP and b-PROTEIN. The human TYRP1 gene encodes a 60724 Da protein containing 537 amino acids. The TYRP1 protein is biasedly expressed in skin, heart and other tissue. Among its related pathways are Aldosterone synthesis and secretion and Viral mRNA Translation. TYRP1 is related to protein homodimerization activity and oxidoreductase activity. DCT is an important paralog of TYRP1 gene. TYRP1 is associated with some diseases, including Albinism, Oculocutaneous, Type Iii and Skin/Hair/Eye Pigmentation, Variation In, 11.

TRP1 Protein (2)

    TRP1 Antibody (3)

      TRP1 cDNA Clone (13)

      NM_000550.2

      克隆载体 cDNA 产品

      In lentiviral vector

      TRP1 qPCR Primer (1)

      TRP1 Lysate (2)

        TRP1 分子背景

        Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

        TRP1 参考文献

        • Sarangarajan R, et al. (2001) Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 14(6): 437-44.
        • Box NF, et al. (1998) Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. Genome. 9 (1): 50-3.

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