UBE2D4 Proteins, Antibodies, cDNA Clones Research Reagents

UBE2D4 (Ubiquitin Conjugating Enzyme E2 D4 (Putative)) is a protein coding gene located on human chromosome 7p13. UBE2D4 is also known as HBUCE1. The human UBE2D4 gene encodes a 16649 Da protein containing 147 amino acids. The UBE2D4 protein is ubiquitously expressed in brain, heart and other tissues. Among its related pathways are Shigellosis and Remodeling of Adherens Junctions. UBE2D4 is related to ligase activity and acid-amino acid ligase activity. UBE2D2 is an important paralog of UBE2D4 gene. UBE2D4 is associated with some diseases, including Brachydactyly, Type E2 and Gordon Holmes Syndrome.

UBE2D4 Protein (1)

    UBE2D4 Antibody (3)

      UBE2D4 cDNA Clone (2)


      In expression vector

      UBE2D4 分子背景

      UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by a ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin-protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans. It has been identified the UBE2D family (UBE2D1-4) as E2 partners for IDOL that support both autoubiquitination and IDOL-dependent ubiquitination of the LDLR in a cell-free system.

      UBE2D4 参考文献

      • Sjoerd J L van Wijk, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol. 5: 317.
      • Zhang L, et al. (2011) The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 25 (12): 1262-74.
      • Nandi D, et al. (2006) The ubiquitin-proteasome system. Journal of biosciences. 31 (1): 137-55.

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