VEGF C Proteins, Antibodies, cDNA Clones Research Reagents

All VEGF C reagents are produced in house and quality controlled, including 2 VEGF C Antibody, 39 VEGF C Gene, 4 VEGF C Lysate, 4 VEGF C Protein, 3 VEGF C qPCR. All VEGF C reagents are ready to use.

VEGF C Protein (4)

    VEGF C Antibody (2)

      VEGF C cDNA Clone (39)

      NM_005429.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_009506.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_053653.1

      克隆载体 cDNA 产品

      In lentiviral vector

      VEGF C Lysate (4)

        VEGF C 分子背景

        Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.

        VEGF C 参考文献

        • Joukov V, et al. (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol. 173(2): 211-5.
        • Su JL, et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96(4): 541-5.
        • Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 104(11): 1302-12.

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