VEGFA Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VEGFA (Vascular Endothelial Growth Factor A) is a protein coding gene located on human chromosome 6p21.1. VEGFA is also known as VPF, VEGF and MVCD1. The human VEGFA gene encodes a 27042 Da protein containing 232 amino acids. The VEGFA protein is broadly expressed in thyroid, prostate and other tissues. Among its related pathways are HIF1Alpha Pathway and Cell adhesion_Plasmin signaling. VEGFA is related to protein homodimerization activity and protein heterodimerization activity. PGF is an important paralog of VEGFA gene. VEGFA is associated with some diseases, including Microvascular Complications Of Diabetes 1 and Poems Syndrome.

VEGFA Antibody (24)

    VEGFA ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

    VEGFA cDNA Clone (104)

    NM_001171625.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001171628.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001171626.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001287058.1

    克隆载体 cDNA 产品

    In lentiviral vector

    AY033506.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001278384.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001278385.1

    克隆载体 cDNA 产品

    In lentiviral vector

    AF133248.1

    克隆载体 cDNA 产品

    In lentiviral vector

    VEGFA Lysate (16)

      VEGFA 分子背景

      Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

      VEGFA 参考文献

      • Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
      • Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
      • Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
      • Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
      • Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
      • Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.

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