Vimentin Proteins, Antibodies, cDNA Clones Research Reagents

All Vimentin reagents are produced in house and quality controlled, including 5 Vimentin Antibody, 23 Vimentin Gene, 1 Vimentin Protein, 2 Vimentin qPCR. All Vimentin reagents are ready to use.

Vimentin Protein (1)

    Vimentin Antibody (5)

      Vimentin cDNA Clone (23)

      NM_003380.2

      In lentiviral vector

      In expression vector

      NM_011701.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_031140.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Vimentin 分子背景

      Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

      Vimentin 参考文献

      • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
      • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
      • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.

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