VNN1 Proteins, Antibodies, cDNA Clones Research Reagents

VNN1 (Vanin 1) is a protein coding gene located on human chromosome 6q23.2. VNN1 is also known as HDLCQ8 and Tiff66. The human VNN1 gene encodes a 57012 Da protein containing 513 amino acids. The VNN1 protein is biasedly expressed in duodenum, liver and other tissues. Among its related pathways are Pantothenate and CoA biosynthesis and Metabolism of proteins. VNN1 is related to hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and GPI anchor binding. VNN2 is an important paralog of VNN1 gene. VNN1 is associated with some diseases, including Obstructive Nephropathy and Malaria.

VNN1 Protein (3)

    VNN1 Antibody (3)

      VNN1 cDNA Clone (38)

      NM_004666.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011704.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001025623.1

      VNN1 Lysate (3)

        VNN1 分子背景

        Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

        VNN1 参考文献

        • Aurrand-Lions M, et al. (1996) Vanin-1, a Novel GPI-Linked Perivascular Molecule Involved in Thymus Homing. Immunity. 5 (5): 391-405.
        • Grimmond S, et al. (2000) Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum Mol Genet. 9 (10): 1553-60.
        • Meghari S, et al. (2007) Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. Eur J Immunol. 37 (1): 24-32.

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