VNN2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VNN2 (Vanin 2) is a protein coding gene located on human chromosome 6q23.2. VNN2 is also known as FOAP-4 and GPI-80. The human VNN2 gene encodes a 58503 Da protein containing 520 amino acids. The VNN2 protein is biasedly expressed in spleen, lymph node and other tissues. Among its related pathways are Pantothenate and CoA biosynthesis and Metabolism of proteins. VNN2 is related to hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and pantetheine hydrolase activity. VNN1 is an important paralog of VNN2 gene. VNN2 is associated with some diseases, including Trichuriasis and Localized Chondrosarcoma.

VNN2 Protein (1)

    VNN2 Antibody (6)

      VNN2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      VNN2 cDNA Clone (14)

      NM_004665.4

      克隆载体 cDNA 产品

      In lentiviral vector

      VNN2 qPCR Primer (1)

      VNN2 Lysate (1)

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        VNN2 分子背景

        Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-8, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein that belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is an amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. It is involved in the thymus homing of bone marrow cells. VNN2 plays a role in transendothelial migration of neutrophils and may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

        VNN2 参考文献

        • Suzuki K. et al., 1999, J. Immunol. 162: 4277-84.
        • Martin, F. et al., 2001,Immunogenetics. 53 (4):296-306.
        • Liu T.et al., 2005, J. Proteome Res. 4: 2070-80.
        • Jansen P.AM. et al., 2009, J. Invest. Dermatol. 129: 2167-74.

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