VWC2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VWC2 (Von Willebrand Factor C Domain Containing 2) is a protein coding gene located on human chromosome 7p12.2. VWC2 is also known as UNQ739 and PSST739. The human VWC2 gene encodes a 35282 Da protein containing 325 amino acids. The VWC2 protein is biasedly expressed in heart, ovary and other tissues. VWC2L is an important paralog of VWC2 gene. VWC2 is associated with some diseases, including Epilepsy, Familial Temporal Lobe, 4 and Spastic Paraplegia 20, Autosomal Recessive.

VWC2 Protein (1)

    VWC2 Antibody (7)

      VWC2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      VWC2 cDNA Clone (13)

      NM_198570

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      In lentiviral vector

      VWC2 qPCR Primer (1)

      VWC2 Lysate (1)

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        VWC2 分子背景

        Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein that contains two VWFC domains. VWC2 / Brorin is a BMP antagonist that may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

        VWC2 参考文献

        • Koike,N. et al., 2007, J Biol Chem. 282 (21):15843-50.
        • Elis,S. et al., 2009,Mol Reprod Dev. 76 (11):1043-55.
        • Zhang,J.L. et al., 2010,PLoS One. 5 (9):e12846.

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