Von Willebrand Factor/vWF Proteins, Antibodies, ELISA Kits Research Reagents

VWF (Von Willebrand Factor) is a protein coding gene located on human chromosome 12p13.31. VWF is also known as VWD and F8VWF. The human VWF gene encodes a 309265 Da protein containing 2813 amino acids. The VWF protein is broadly expressed in fat, lung and other tissues. Among its related pathways are RET signaling and Paradoxical activation of RAF signaling by kinase inactive BRAF. VWF is related to protein homodimerization activity and integrin binding. MUC5AC is an important paralog of VWF gene. VWF is associated with some diseases, including Von Willebrand Disease, Type 1 and Von Willebrand Disease, Type 2.

Von Willebrand Factor/vWF Protein (1)

    Von Willebrand Factor/vWF Antibody (7)

      Von Willebrand Factor/vWF ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      Von Willebrand Factor/vWF Lysate (1)

        Von Willebrand Factor/vWF 分子背景

        Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.

        Von Willebrand Factor/vWF 参考文献

        • Sadler JE. (1998) Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 67: 395-424.
        • Batlle J, et al. (2009) Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. Blood Coagul Fibrinolysis. 20(2):89-100.
        • Sadler JE. (2009) von Willebrand factor assembly and secretion. J Thromb Haemost. 7 Suppl 1:24-7.
        • Auton M, et al. (2010) The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 99(4):1192-201.
        • Bowen DJ. (2010) Sugar targets VWF for the chop. Blood. 115(13):2565.
        • Lpez JA, et al. (2010) VWF self-association: more bands for the buck. Blood. 116(19):3693-4.

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