WNV prM protein and Envelope Antibodies, cDNA Clones Research Reagents

West Nile virus (WNV) is a mosquito-borne neurotropic member of this genus that is an emerging pathogen. Envelope protein (E) is a protein of about 53kDa that mediates virus attachment to cells and drives the pH-dependent fusion of viral and cellular membranes in the endosomes of infected cells. On immature virions, the premembrane (prM) protein interacts with the E protein to form 60 heterotrimeric spikes, and functions to prevent adventitious fusion between viral and cellular membranes during egress through acidic compartments of the secretory pathway.

WNV prM protein and Envelope Antibody (5)

    WNV prM protein and Envelope cDNA Clone (15)

    Lineage 1, strain NY99, Isolate 385-99

    克隆载体 cDNA 产品

    In lentiviral vector

    WNV prM protein and Envelope 分子背景

    Flaviviruses are a group of positive-stranded RNA viruses. West Nile virus (WNV) is a mosquito-borne neurotropic member of this genus that is an emerging pathogen. The envelope (E) protein is an approximately 53-kDa protein that mediates virus attachment to cells and drives the pH-dependent fusion of viral and cellular membranes in the endosomes of infected cells. On immature virions, the 20-kDa premembrane (prM) protein interacts with the E protein to form 60 heterotrimeric spikes and functions to prevent adventitious fusion between viral and cellular membranes during egress through acidic compartments of the secretory pathway. Transit through these compartments catalyzes a pH-dependent rearrangement of prM and E proteins on the virion that exposes a recognition motif on prM for cellular furin-like serine proteases.

    WNV prM protein and Envelope 参考文献

    • Setoh YX, et al. (2012) Identification of residues in west nile virus pre-membrane protein that influence viral particle secretion and virulence. J Gen Virol 93 (Pt 9): 1965-1975.
    • Mukherjee S, et al. (2011) The infectivity of prm-containing partially mature west nile virus does not require the activity of cellular furin-like proteases. J Virol 85 (22): 12067-12072.
    • Calvert AE, et al. (2012) Mutations in the west nile prm protein affect vlp and virion secretion in vitro. Virology 433 (1): 35-44.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.