XPNPEP2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

XPNPEP2 (X-Prolyl Aminopeptidase 2) is a protein coding gene located on human chromosome Xq26.1. XPNPEP2 is also known as APP2 and AEACEI. The human XPNPEP2 gene encodes a 75625 Da protein containing 674 amino acids. The XPNPEP2 protein is biasedly expressed in small intestine, kidney and other tissue. Among its related pathways are Collagen chain trimerization and Metabolism of proteins. XPNPEP2 is related to hydrolase activity and aminopeptidase activity. XPNPEP1 is an important paralog of XPNPEP2 gene. XPNPEP2 is associated with some diseases, including Angioedema Induced By Ace Inhibitors and Angioedema.

XPNPEP2 Protein (1)

    XPNPEP2 Antibody (7)

      XPNPEP2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      XPNPEP2 cDNA Clone (2)

      BC126174

      In expression vector

      In lentiviral vector

      XPNPEP2 qPCR Primer (1)

      XPNPEP2 Lysate (1)

        XPNPEP2 分子背景

        Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).

        XPNPEP2 参考文献

        • Sprinkle TJ, et al. (2000) Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. Arch Biochem Biophys. 378(1): 51-6.
        • Prueitt RL, et al. (2000) Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Cytogenet Cell Genet. 89(1-2): 44-50.
        • Duan QL, et al. (2005) A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 77(4): 617-26.
        • Woodard-Grice AV, et al. (2010) Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 20(9): 532-6.

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