ZIKV prM protein and Envelope cDNA Clones Research Reagents

The Zika Virus RNA genome encodes one open reading frame (ORF) that is post-translationally processed into three structural proteins (C, capsid; prM, pre-membrane; E, envelope) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). The outer surface of mature ZIKV virion consists of 180 copies of E glycoproteins, which is arranged into 90 antiparallel homodimers and anchored onto the virus lipid envelope via a transmembrane domain. The N-terminal ectodomain of an individual E glycoprotein mediates viral attachment and post-entry endosomal fusion during the virus entry process.

ZIKV prM protein and Envelope cDNA Clone (3)

ZikaSPH2015

In expression vector

In lentiviral vector

ZIKV prM protein and Envelope 分子背景

The function of Zika virus prM and M is assisting the folding and secretion of E protein. Antibodies toward prM can enhance infectivity of immature virions. E protein of Zika virus plays an important role in receptor binding and membrane fusion.

ZIKV prM protein and Envelope 参考文献

  • Pinto Júnior VL, et al. Zika virus: a review to clinicians, Acta Med Port 2015 Nov-Dec;28(6):760-765
  • Wong SS-Y, et al., Zika virus infectiondthe next wave after dengue?, Journal of the Formosan Medical Association (2016)

Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.