CD38 Protein, Human, Recombinant (His Tag)

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CD38 Protein, Human, Recombinant (His Tag): 产品信息

纯度
> 97 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
1. Measured by its ability to convert the substrate nicotinamide guanine dinucleotide
(NGD+) to cyclic GDPribose.The specific activity is > 2,500 pmoles/min/μg.
2. Measured by its binding ability in a functional ELISA. Immobilized human CD38 (Cat:10818-H08H) at 0.1μg/ml (100 μL/well) can bind anti-human CD38 Mab with a linear range of 3.9-500 ng/ml.
蛋白构建
A DNA sequence encoding the extracellular domain of human CD38 (NP_001766.2) (Val 43-Ile 300) with a C-terminal polyhistidine tag was expressed.
NP No.
表达宿主
HEK293 Cells
种属
Human
预测 N 端
Val 43
分子量
The secreted recombinant human CD38 comprises 269 amino acids with a predicted molecular mass of 31.3 kDa. As a result of glycosylation, rhCD38 migrates as an approximately 43-45 kDa band in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD38 Protein, Human, Recombinant (His Tag): 图片

Measured by its binding ability in a functional ELISA. Immobilized human CD38 (Cat:10818-H08H) at 0.1μg/ml (100 μL/well) can bind anti-human CD38 Mab with a linear range of 3.9-500 ng/ml.

CD38 Protein, Human, Recombinant (His Tag): 别称

ADPRC 1 Protein, Human; ADPRC1 Protein, Human; T10 Protein, Human

CD38 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.
全称
CD38 molecule
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Novel anti-CD38 humanized mAb SG003 possessed enhanced cytotoxicity in lymphoma than Daratumumab via antibody-dependent cell-mediated cytotoxicity
    Author
    Yu, T;Qiao, C;Lv, M;Tang, L;
    Year
    2019
    Journal
    BMC Biotechnol.
    Application
    ELISA and SPR
  • Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells
    Author
    Gao, Z;Tong, C;Wang, Y;Chen, D;Wu, Z;Han, W;
    Year
    2019
    Journal
    J Genet Genomics
    Application
    cell-based
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