Anti-CD5 Antibody (APC)

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Anti-CD5 Antibody (APC) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-CD5 Antibody (APC)
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse CD5
免疫原
Recombinant Mouse CD5 protein (Catalog#50403-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD5 (rM CD5; Catalog#50403-M08H; NP_031676.3; Met1-Pro371) and conjugated with APC under optimum conditions, the unreacted APC was removed.
来源
Monoclonal Rabbit IgG Clone #114
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
APC
浓度
2 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD5 Antibody (APC) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of mouse CD5 expression on splenocytes.

Anti-CD5 Antibody (APC): 别称

Anti-Ly-1 Antibody; Anti-Ly-12 Antibody; Anti-Ly-A Antibody; Anti-Lyt-1 Antibody

CD5 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD5 is a member of the CD system. CD5 was found to be widely distributed in T-cells and B1 cells which is a subset of IgM-secreting B cells. CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. CD5 serves to weaken the activating stimulus from the BCR so that the B1 cells can only reflect to the very strong stimuli but not the normal tissue proteins.
全称
CD5 molecule
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters. 134 (2): 104-12.
  • Kirchgessner H, et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 193 (11): 1269-84.
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