Anti-B7-1 Antibody (PE)

1/1
Price:
Size:
Number:

Anti-B7-1 Antibody (PE) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-B7-1 Antibody (PE)
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse B7-1
免疫原
Recombinant Mouse CD80/B7-1 Protein (Catalog#50446-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD80/B7-1 (rM CD80/B7-1; Catalog#50446-M08H; Q00609-1; Met1-Lys245) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Rabbit IgG Clone #014
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-B7-1 Antibody (PE) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of Mouse CD80 expression on BABL/c splenocytes. Cells were stained with PE-conjugated anti-Mouse CD80. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-B7-1 Antibody (PE): 别称

Anti-B71 Antibody; Anti-Cd28l Antibody; Anti-Ly-53 Antibody; Anti-Ly53 Antibody; Anti-MIC17 Antibody; Anti-TSA1 Antibody

B7-1 背景信息

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD8, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD8 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
全称
CD80 molecule
参考文献
  • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
  • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
  • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后