Abl-interactor 2 (Abi2) is known as a tumor suppressor and a cell migration inhibitor. Abelson (Abl) interactor 2 (Abi-2) has been considered as a key regulator of cell/tissue structural organization and is differentially expressed in leiomyomas,which had been proved a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression.