AMPK alpha 1/PRKAA1 cDNA ORF Clone, Human, N-HA tag

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AMPK alpha 1/PRKAA1 cDNA ORF Clone, Human, N-HA tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1722 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human protein kinase, AMP-activated, alpha 1 catalytic subunit with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
限制性酶切位点
KpnI + XbaI(6kb+1.72kb)
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

AMPK alpha 1/PRKAA1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

AMPK alpha 1/PRKAA1 cDNA ORF Clone, Human, N-HA tag: 验证图片

AMPK alpha 1/PRKAA1 cDNA ORF Clone, Human, N-HA tag: 别称

AMPK cDNA ORF Clone, Human; AMPKa1 cDNA ORF Clone, Human

AMPK alpha 1/PRKAA1 背景信息

The PRKAA1 gene encodes the catalytic alpha-subunit of 5' AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that maintains energy homeostasis within the cell and is activated when the AMP/ATP ratio increases. Moreover, AMPK has been shown to be involved in inhibiting tumour growth and metastasis, and has also been implicated in the pathology of neurodegenerative and cardiac disorders. All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.An inhibitor of PRKAA1 promoted the secretion of IL6, whereas an agonist of PRKAA1 suppressed the production of IL6.
全称
protein kinase, AMP-activated, alpha 1 catalytic subunit
Related Pathways
  • AMPK Signaling Pathway
    AMPK Signaling Pathway
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
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