CCR4/CD194 cDNA ORF Clone, Human, untagged

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CCR4/CD194 cDNA ORF Clone, Human, untagged: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1083 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human chemokine (C-C motif) receptor 4.
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
HindIII + XbaI (6.1kb + 1.08kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

CCR4/CD194 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CCR4/CD194 cDNA ORF Clone, Human, untagged: 验证图片

CCR4/CD194 cDNA ORF Clone, Human, untagged: 别称

CC-CKR-4 cDNA ORF Clone, Human; CD194 cDNA ORF Clone, Human; ChemR13 cDNA ORF Clone, Human; CKR4 cDNA ORF Clone, Human; CMKBR4 cDNA ORF Clone, Human; HGCN:14099 cDNA ORF Clone, Human; K5-5 cDNA ORF Clone, Human

CCR4/CD194 背景信息

CCR4 is a chemokine receptor that has a critical role in immune cell trafficking. T-helper type 2 cells (Th2), regulatory T cells (Treg), interluekin-17–producing T-helper cells (Th17), and skin-homing memory T cells express CCR4 on their surface and migrate toward the chemokines CCL17 and CCL22. CCR4, a C-C type chemokine receptor, has previously been focused on its biological function in immunopathogenesis of hematological tumors. To date, relatively little attention has been paid to the role of CCR4 in promoting metastasis of some solid tumors, including gastric cancer. Our group has shown that the lymphocyte-rich gastric cancers tend to be more frequently positive for CCR4, and found a novel role of CCR4 in tumor-induced immunosuppression, indicating various expression profiles of CCR4 in gastric cancer tissues and multifunctional roles of this molecule in gastric cancer progression.
全称
chemokine (C-C motif) receptor 4
研究领域
参考文献
  • Yang Y, Du L, Yang X, et al. Aberrant CCR4 Expression Is Involved in Tumor Invasion of Lymph Node-Negative Human Gastric Cancer. Tang C-H, ed. PLoS ONE. 2015;10(3):e0120059. doi:10.1371/journal.pone.0120059.
  • Nakagawa M, Schmitz R, Xiao W, et al. Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. The Journal of Experimental Medicine. 2014;211(13):2497-2505.
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