ELF3 cDNA ORF Clone in Cloning Vector, Human

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ELF3 cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1116 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 573T/C not causing the amino acid variation.
产品特征
Full length Clone DNA of Human E74 like ETS transcription factor 3
质粒
载体
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ELF3 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ELF3 cDNA ORF Clone in Cloning Vector, Human: 别称

EPR-1 cDNA ORF Clone, Human; ERT cDNA ORF Clone, Human; ESE-1 cDNA ORF Clone, Human; ESX cDNA ORF Clone, Human

ELF3 背景信息

Chromosomal translocations leading to deregulated expression of ETS transcription factors are frequent in prostate tumors. ESE1/ELF3 was induced by interleukin (IL)-1beta through NF-kappaB and was a crucial mediator of the phenotypic and transcriptional changes induced by IL-1beta in prostate cancer cells. ESE1/ELF3 was overexpressed in human primary and metastatic tumors. E74-like factor 3 (ELF3) protein levels are increased in osteoarthritic (OA) cartilage, that ELF3 accounts for inflammatory cytokine-driven MMP13 gene expression, and that, upon induction by interleukin-1beta, ELF3 binds to the COL2A1 promoter and suppresses its activity in chondrocytes. ELF3 is a favorable prognostic marker for ovarian cancer. As a negative regulator of EMT, ELF3-modulated reversal of EMT may be a new effective modality in the treatment of ovarian cancer.
全称
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
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