ERCC6L cDNA ORF Clone, Human, C-OFPSpark® tag

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ERCC6L cDNA ORF Clone, Human, C-OFPSpark® tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
4440 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 2286T/C,2493A/T not causing the amino acid variation.
产品特征
Full length Clone DNA of Human ERCC excision repair 6 like, spindle assembly checkpoint helicase.
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
KpnI + NotI(6kb+4.48kb)
标签序列
OFPSpark Tag: GATAGCACTGAG……CACCTGTTCCAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' ) BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ERCC6L cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 ERCC6L的更多信息

Entrez Gene ID

ERCC6L cDNA ORF Clone, Human, C-OFPSpark® tag: 别称

PICH cDNA ORF Clone, Human; RAD26L cDNA ORF Clone, Human

ERCC6L 背景信息

A newly identified ERCC6-like gene in mice, ERCC6L, also known as polo-like kinase 1 (PLK1)-interacting checkpoint helicase, has been demonstrated to be a development-associated member of the SNF2 family. Excision repair cross-complementation group 6 like (ERCC6L) is highly expressed in a variety of human cancer types. The ERCC6L protein is assembled in the cytoplasm and then enters the cell nucleus to exert its function. It is strongly expressed in the mouse embryonic stage, particularly in embryonic brain, heart, kidney, liver and lung. ERCC6L silencing has been revealed to inhibit the proliferation of cancer cells, which suggests that ERCC6L may be an effective biomarker for cancer progression.
参考文献
  • Huang Y, et al. (2019) Loss of pich promotes chromosome instability and cell death in triple-negative breast cancer. Cell Death Dis 10 (6): 428.
  • Zhang G, et al. (2019) Ercc6l that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating mapk signalling pathway. Cancer Gene Ther 26 (9-10): 323-333.
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