The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
储存 & 运输
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.
ERCC6L cDNA ORF 核苷酸序列及氨基酸序列信息
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PICH cDNA ORF Clone, Human; RAD26L cDNA ORF Clone, Human
A newly identified ERCC6-like gene in mice, ERCC6L, also known as polo-like kinase 1 (PLK1)-interacting checkpoint helicase, has been demonstrated to be a development-associated member of the SNF2 family. Excision repair cross-complementation group 6 like (ERCC6L) is highly expressed in a variety of human cancer types. The ERCC6L protein is assembled in the cytoplasm and then enters the cell nucleus to exert its function. It is strongly expressed in the mouse embryonic stage, particularly in embryonic brain, heart, kidney, liver and lung. ERCC6L silencing has been revealed to inhibit the proliferation of cancer cells, which suggests that ERCC6L may be an effective biomarker for cancer progression.
Huang Y, et al. (2019) Loss of pich promotes chromosome instability and cell death in triple-negative breast cancer. Cell Death Dis 10 (6): 428.
Zhang G, et al. (2019) Ercc6l that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating mapk signalling pathway. Cancer Gene Ther 26 (9-10): 323-333.