GAP43 cDNA ORF Clone, Human, C-GFPSpark® tag
GAP43 cDNA ORF Clone, Human, C-GFPSpark® tag: 产品信息
基因
种属
Human
NCBI 参考序列号
基因长度
1446 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human growth associated protein 43.
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
KpnI + XbaI(6kb+1.45kb)
标签序列
GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' ) BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.
GAP43 cDNA ORF 核苷酸序列及氨基酸序列信息
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
GAP43 cDNA ORF Clone, Human, C-GFPSpark® tag: 验证图片
GAP43 cDNA ORF Clone, Human, C-GFPSpark® tag: 别称
B-50 cDNA ORF Clone, Human; PP46 cDNA ORF Clone, Human
GAP43 背景信息
Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.
全称
growth associated protein 43
参考文献
- Frey,D. et al., 2000, J Cell Biol. 149 (7):1443-54.
- Caprini,M. et al., 2003, EMBO J. 22 (12):3004-14.
- Sawaguchi,T. et al., 2003, Early Hum Dev. 75 Suppl :S139-46.
- Kowara,R. et al., 2007, Biochem Biophys Res Commun 363 (1):190-3.
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