IL-6R cDNA ORF Clone in Cloning Vector, Human

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IL-6R cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1407 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human interleukin 6 receptor, transcript variant 1.
质粒
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

IL-6R cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

IL-6R cDNA ORF Clone in Cloning Vector, Human: 别称

CD126 cDNA ORF Clone, Human; gp80 cDNA ORF Clone, Human; IL-6R cDNA ORF Clone, Human; IL-6R-1 cDNA ORF Clone, Human; IL-6RA cDNA ORF Clone, Human; IL6Q cDNA ORF Clone, Human; IL6RA cDNA ORF Clone, Human; IL6RQ cDNA ORF Clone, Human

IL-6R 背景信息

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
全称
interleukin 6 receptor
研究领域
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参考文献
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.

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