MTFR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag

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MTFR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1002 bp
序列特征
Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence)
产品特征
Full length Clone DNA of Homo sapiens mitochondrial fission regulator 1.
质粒
启动子
Enhanced CMV mammalian cell promoter
标签序列
GFPSpark Tag Sequence: GTGAGCAAGGGC……GAGCTGTACAAG
测序引物
pLen-F(CTCGTTTAGTGAACCGTCAGAATT), pLen-R(GAACCGGAACCCTTAAACATGT)
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains 10μg lyophilized plasmid
储存条件
The lyophilized plasmid can be stored at room temperature for three months

MTFR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 别称

CHPPR cDNA ORF Clone, Human; FAM54A2 cDNA ORF Clone, Human

MTFR1 背景信息

The Mtfr1 has been confirmed as a targeted gene of miR-324-5p through miRTarBase software and western blot. miR-324-5p protects against oxidative stress-induced EPCs injury by regulating Mtfr1. Knocking down Mtfr1 suppresses mitochondrial fission, apoptosis, and myocardial infarction. Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation. Mtfr1 (mitochondrial fission regulator 1), is a gene involved in the regulation of antioxidant activity in the mouse testis. Mtfr1 protects the male gonads against oxidative stress. Mtfr1/Chppr is a nuclear gene coding for a mitochondrial protein capable of inducing fission of this organelle in a sequence-specific manner.
全称
mitochondrial fission regulator 1
参考文献
  • Wang K, et al. (2015) Nfat4-dependent mir-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting mtfr1. Cell Death Dis 6 (12): e2007.
  • Monticone M, et al. (2007) Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of mtfr1/chppr-deficient mice. Reproduction 134 (3): 483-492.
  • Chen P, et al. (2019) Mir-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting mtfr1. J Cell Physiol 234 (12): 22082-22092.
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