MUC1 cDNA ORF Clone, Human, C-Myc tag

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MUC1 cDNA ORF Clone, Human, C-Myc tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
795 bp
产品特征
Full length Clone DNA of Human mucin 1, cell surface associated, transcript variant 2 with C terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MUC1 cDNA ORF Clone, Human, C-Myc tag: 别称

ADMCKD cDNA ORF Clone, Human; ADMCKD1 cDNA ORF Clone, Human; CA15-3 cDNA ORF Clone, Human; CD227 cDNA ORF Clone, Human; EMA cDNA ORF Clone, Human; H23AG cDNA ORF Clone, Human; KL-6 cDNA ORF Clone, Human; MAM6 cDNA ORF Clone, Human; MCD cDNA ORF Clone, Human; MCKD cDNA ORF Clone, Human; MCKD1 cDNA ORF Clone, Human; MUC-1 cDNA ORF Clone, Human; MUC-1/SEC cDNA ORF Clone, Human; MUC-1/X cDNA ORF Clone, Human; MUC1/ZD cDNA ORF Clone, Human; Mucin 1 cDNA ORF Clone, Human; PEM cDNA ORF Clone, Human; PEMT cDNA ORF Clone, Human; PUM cDNA ORF Clone, Human

MUC1 背景信息

Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach, and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized, and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC, and NF-kappa-B pathways. In the activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
全称
mucin 1, cell surface associated
研究领域
Related Pathways
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
参考文献
  • Brayman M, et al. (2004) MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2: 4.
  • Schroeder J A, et al. (2001) Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276 (16): 13057-64.
  • Li Y, et al. (2001) The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 276 (38): 35239-42.
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