NANS cDNA ORF Clone in Cloning Vector, Human

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NANS cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1080 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 153T/C not causing the amino acid variation;204G/C(E68D);208C/T(P70S).
产品特征
Full length Clone DNA of Human N-acetylneuraminate synthase
质粒
载体
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

NANS cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 NANS的更多信息

Entrez Gene ID

NANS cDNA ORF Clone in Cloning Vector, Human: 别称

HEL-S-100 cDNA ORF Clone, Human; SAS cDNA ORF Clone, Human; SEMDCG cDNA ORF Clone, Human; SEMDG cDNA ORF Clone, Human

NANS 背景信息

NANS (N-Acetylneuraminate Synthase) is a Protein Coding gene. The NANS gene, located on 9q22.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. Diseases associated with NANS include Spondyloepimetaphyseal Dysplasia, Genevieve Type, and Cleft Palate, Isolated. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins.
全称
N-acetylneuraminic acid synthase
参考文献
  • van Karnebeek CD, et al. (2016) Nans-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet 48 (7): 777-784.
  • Lawrence SM, et al. (2000) Cloning and expression of the human n-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-d-glycero- d-galacto-nononic acid biosynthetic ability. J Biol Chem 275 (23): 17869-17877.
  • Hamada T, et al. (2006) Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci 15 (5): 1010-1016.
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