PPIP5K2 cDNA ORF Clone in Cloning Vector, Human

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PPIP5K2 cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
3375 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human diphosphoinositol pentakisphosphate kinase 2
质粒
载体
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

PPIP5K2 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 PPIP5K2的更多信息

Entrez Gene ID

PPIP5K2 cDNA ORF Clone in Cloning Vector, Human: 别称

CFAP160 cDNA ORF Clone, Human; HISPPD1 cDNA ORF Clone, Human; IP7K2 cDNA ORF Clone, Human; VIP2 cDNA ORF Clone, Human

PPIP5K2 背景信息

The diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) plays critical roles in cell signaling and bioenergetic homeostasis. PPIP5K2 is remarkable for the reversible nature of its kinase activity, its unique ligand-stimulated ATPase activity, and the substrate traveling between two ligand-binding sites. PPIP5K2 mediates cellular phosphate homestasis, since its kinase activity acts as a sensor of extracellular inorganic phosphate levels, dysfunctional PPIP5K2 activity in the inner ear results in hair cell loss and deafness. Mutations in PPIP5K2 gene are associated with hearing loss in human and mouse.
参考文献
  • Yousaf R, et al. (2018) Mutations in diphosphoinositol-pentakisphosphate kinase ppip5k2 are associated with hearing loss in human and mouse. PLoS Genet 14 (3): e1007297.
  • Wang H, et al. (2014) Synthetic inositol phosphate analogs reveal that ppip5k2 has a surface-mounted substrate capture site that is a target for drug discovery. Chem Biol 21 (5): 689-699.
  • An Y, et al. (2019) Dynamics of substrate processing by ppip5k2, a versatile catalytic machine. Structure 27 (6): 1022-1028.e1022.
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