The plasmid is confirmed by full-length sequencing.
储存 & 运输
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
PPIP5K2 cDNA ORF 核苷酸序列及氨基酸序列信息
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
The diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) plays critical roles in cell signaling and bioenergetic homeostasis. PPIP5K2 is remarkable for the reversible nature of its kinase activity, its unique ligand-stimulated ATPase activity, and the substrate traveling between two ligand-binding sites. PPIP5K2 mediates cellular phosphate homestasis, since its kinase activity acts as a sensor of extracellular inorganic phosphate levels, dysfunctional PPIP5K2 activity in the inner ear results in hair cell loss and deafness. Mutations in PPIP5K2 gene are associated with hearing loss in human and mouse.
Yousaf R, et al. (2018) Mutations in diphosphoinositol-pentakisphosphate kinase ppip5k2 are associated with hearing loss in human and mouse. PLoS Genet 14 (3): e1007297.
Wang H, et al. (2014) Synthetic inositol phosphate analogs reveal that ppip5k2 has a surface-mounted substrate capture site that is a target for drug discovery. Chem Biol 21 (5): 689-699.
An Y, et al. (2019) Dynamics of substrate processing by ppip5k2, a versatile catalytic machine. Structure 27 (6): 1022-1028.e1022.