SLC38A1 (Solute Carrier Family 38 Member 1) is a Protein Coding gene. The SLC38A1 gene, located on 12q13.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate. SLC38A1 is widely expressed in the lymph node, thyroid, and other tissues. Diseases associated with SLC38A1 include Klatskin's Tumor. SLC38A1 is associated with the occurrence and progression of solid tumors. Further, glutamine transporter SLC38A1 might serve as a potential target for the development of novel therapeutic drugs in the treatment of acute myeloid leukemia (AML).
solute carrier family 38, member 1
Qureshi T, et al. (2020) Slc38a1 conveys astroglia-derived glutamine into gabaergic interneurons for neurotransmitter gaba synthesis. Cells 9 (7): 1686.
Qureshi T, et al. (2019) The glutamine transporter slc38a1 regulates gabaergic neurotransmission and synaptic plasticity. Cereb Cortex 29 (12): 5166-5179.
Li Y, et al. (2019) High expression of slc38a1 predicts poor prognosis in patients with de novo acute myeloid leukemia. J Cell Physiol 234 (11): 20322-20328.