SLUG cDNA ORF Clone, Human, C-OFPSpark® tag

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SLUG cDNA ORF Clone, Human, C-OFPSpark® tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
807 bp
产品特征
Full length Clone DNA of Human snail homolog 2 (Drosophila) with C terminal OFPSpark / RFP tag.
质粒
启动子
Enhanced CMV promoter
标签序列
OFPSpark Tag: GATAGCACTGAG……CACCTGTTCCAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

SLUG cDNA ORF Clone, Human, C-OFPSpark® tag: 别称

SLUG cDNA ORF Clone, Human; SLUGH1 cDNA ORF Clone, Human; SNAIL2 cDNA ORF Clone, Human; WS2D cDNA ORF Clone, Human

SLUG 背景信息

SNAI2 is a key regulator of the aggressive phenotype observed in endocrine-resistant breast cancer cells, an independent prognostic biomarker in ER+ advanced breast cancer treated with endocrine therapy, and may be a promising therapeutic target in combination with endocrine therapies in ER+ metastatic breast cancer exhibiting high SNAI2 levels. SNAI2 transformed normal fibroblasts to a CAF-like state and boosted their tumor-supporting role in 3D organotypic culture and in OC xenograft model. SNAI2 drove a transcriptional signature in the mesenchymal subtype of OC that contributed to tumor desmoplasia, which fed back to increase SNAI2 expression and sustain fibroblast activation.
全称
snail family zinc finger 2
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