ST2/IL-1 RL1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag

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ST2/IL-1 RL1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
987 bp
序列特征
Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence)
产品特征
Full length Clone DNA of Homo sapiens interleukin 1 receptor-like 1, transcript variant 2.
质粒
启动子
Enhanced CMV mammalian cell promoter
标签序列
GFPSpark Tag Sequence: GTGAGCAAGGGC……GAGCTGTACAAG
测序引物
pLen-F(CTCGTTTAGTGAACCGTCAGAATT), pLen-R(GAACCGGAACCCTTAAACATGT)
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains 10μg lyophilized plasmid
储存条件
The lyophilized plasmid can be stored at room temperature for three months

ST2/IL-1 RL1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 别称

DER4 cDNA ORF Clone, Human; FIT-1 cDNA ORF Clone, Human; IL1RL1 cDNA ORF Clone, Human; IL33R cDNA ORF Clone, Human; IL‑1 R4 cDNA ORF Clone, Human; ST2 cDNA ORF Clone, Human; ST2L cDNA ORF Clone, Human; ST2V cDNA ORF Clone, Human; T1 cDNA ORF Clone, Human

ST2/IL-1 RL1 背景信息

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
全称
interleukin 1 receptor-like 1
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

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