SUCLA2 cDNA ORF Clone in Cloning Vector, Human

Price:
Size:
Number:

SUCLA2 cDNA ORF Clone in Cloning Vector, Human: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
1392 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 595T/A(S199T)
产品特征
Full length Clone DNA of Human succinate-CoA ligase ADP-forming beta subunit
质粒
载体
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

SUCLA2 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 SUCLA2的更多信息

Entrez Gene ID

SUCLA2 cDNA ORF Clone in Cloning Vector, Human: 别称

A-BETA cDNA ORF Clone, Human; A-SCS cDNA ORF Clone, Human; MTDPS5 cDNA ORF Clone, Human; SCS-betaA cDNA ORF Clone, Human

SUCLA2 背景信息

SUCLA2 encodes the ATP-forming β subunit (A-SUCL-β) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Sucla2 is located in the mitochondrial matrix and catalyzes the reversible synthesis of succinate and adenosine triphosphate (ATP) in the tricarboxylic acid cycle. Mutations in SUCLA2, encoding the ß-subunit of succinyl-CoA synthetase of the Krebs cycle, are one cause of mitochondrial DNA depletion syndrome. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness, and lesions in the basal ganglia. Patients have been reported to have severe progressive childhood-onset encephalomyopathy, and methylmalonic aciduria, often leading to death in childhood. Sucla2 expression was found to be correlated with the capacitation of boar spermatozoa. The metabolic vulnerability in SUCLA2-deficient prostate cancer cells is pharmacologically targetable.
全称
succinate-CoA ligase, ADP-forming, beta subunit
参考文献
  • Matilainen S, et al. (2017) Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of sucla2 point mutation and 13q14 deletion. Eur J Hum Genet 25 (3): 393.
  • Huang S, et al. (2016) Knockdown of sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells. Folia Histochem Cytobiol 54 (3): 134-142.
  • Dobolyi A, et al. (2015) Exclusive neuronal expression of sucla2 in the human brain. Brain Struct Funct 220 (1): 135-151.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.