TCF4/E2-2 cDNA ORF Clone, Human, C-Myc tag

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TCF4/E2-2 cDNA ORF Clone, Human, C-Myc tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
2016 bp
产品特征
Full length Clone DNA of Human transcription factor 4 with C terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

TCF4/E2-2 cDNA ORF Clone, Human, C-Myc tag: 别称

bHLHb19 cDNA ORF Clone, Human; E2-2 cDNA ORF Clone, Human; ITF-2 cDNA ORF Clone, Human; ITF2 cDNA ORF Clone, Human; PTHS cDNA ORF Clone, Human; SEF-2 cDNA ORF Clone, Human; SEF2 cDNA ORF Clone, Human; SEF2-1 cDNA ORF Clone, Human; SEF2-1A cDNA ORF Clone, Human; SEF2-1B cDNA ORF Clone, Human; SEF2-1D cDNA ORF Clone, Human; TCF-4 cDNA ORF Clone, Human

TCF4/E2-2 背景信息

Transcription factor 7 like 2 (TCF7L2, also known as TCF4) is a Wnt signaling pathway transcription factor involved in the regulation of numerous Wnt targeted genes. TCF4 is critical in the vertebrate intestinal epithelium, where TCF4-β-catenin complexes are necessary for the maintenance of a proliferative compartment, and their abnormal formation initiates tumorigenesis. β-catenin, an upstream protein of TCF4, accumulates in the cytoplasm, then translocates to the nucleus to activate the β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional machinery and regulates target genes. Previous studies showed that TCF4 was involved in cell proliferation and apoptosis. Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language impairment and development delay.
全称
transcription factor 4
Related Pathways
  • Canonical Wnt Pathway
    Canonical Wnt Pathway
  • Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway
参考文献
  • Liu X, et al. (2016) T-cell factor (tcf/lef1) binding elements (tbes) of fasl (fas ligand or cd95 ligand) bind and cluster fas (cd95) and form complexes with the tcf-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation. Cell Mol Neurobiol 36 (6): 1001-1013.
  • Lan F, et al. (2012) Genome-wide identification of tcf7l2/tcf4 target mirnas reveals a role for mir-21 in wnt-driven epithelial cancer. Int J Oncol 40 (2): 519-526.
  • Kennedy AJ, et al. (2016) Tcf4 regulates synaptic plasticity, DNA methylation, and memory function. Cell Rep 16 (10): 2666-2685.
  • Costa AM, et al. (2013) Grg5/aes interacts with t-cell factor 4 (tcf4) and downregulates wnt signaling in human cells and zebrafish embryos. PLoS One 8 (7): e67694.
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