4-1BBL/TNFSF9 cDNA ORF Clone, Mouse, N-HA tag

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4-1BBL/TNFSF9 cDNA ORF Clone, Mouse, N-HA tag: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
930 bp
产品特征
Full length Clone DNA of Mouse tumor necrosis factor (ligand) superfamily, member 9 with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

4-1BBL/TNFSF9 cDNA ORF Clone, Mouse, N-HA tag: 别称

4-1BB-L cDNA ORF Clone, Mouse; 4-1BBL cDNA ORF Clone, Mouse; AI848817 cDNA ORF Clone, Mouse; Cd137l cDNA ORF Clone, Mouse; Ly63l cDNA ORF Clone, Mouse

4-1BBL/TNFSF9 背景信息

4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
全称
tumor necrosis factor (ligand) superfamily, member 9
研究领域
参考文献
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.

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