ICAM4 cDNA ORF Clone, Mouse, untagged

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ICAM4 cDNA ORF Clone, Mouse, untagged: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
789 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Mouse intercellular adhesion molecule 4, Landsteiner-Wiener blood group.
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
HindIII + XbaI(6.1kb+0.79kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' ) BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ICAM4 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 ICAM4的更多信息

Entrez Gene ID

ICAM4 cDNA ORF Clone, Mouse, untagged: 验证图片

ICAM4 cDNA ORF Clone, Mouse, untagged: 别称

1810015M19Rik cDNA ORF Clone, Mouse; Cd242 cDNA ORF Clone, Mouse; ICAM-4 cDNA ORF Clone, Mouse

ICAM4 背景信息

ICAM4, also known as CD242, is a member of the immunoglobulin superfamily, the ICAM family. ICAM4 contains 2 Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in the spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in the removal of senescent red cells.
全称
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Related Pathways
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    Actin Dynamics Signaling Pathway
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    MAPK-Erk Pathway
  • Autophagy Pathway
    Autophagy Pathway
参考文献
  • Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
  • Vos GH. et al., 1973, Blood. 42 (3): 445-53.
  • Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
  • Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.
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