SLC1A5 cDNA ORF Clone in Cloning Vector, Mouse


SLC1A5 cDNA ORF Clone in Cloning Vector, Mouse: 产品信息

NCBI 参考序列号
1668 bp
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 846C>A not causing the amino acid variation.
Full length Clone DNA of Mouse solute carrier family 1 (neutral amino acid transporter), member 5.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
储存 & 运输
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

SLC1A5 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SLC1A5 cDNA ORF Clone in Cloning Vector, Mouse: 别称

AAAT cDNA ORF Clone, Mouse; ASCT2 cDNA ORF Clone, Mouse; ATBO cDNA ORF Clone, Mouse; M7V1 cDNA ORF Clone, Mouse; M7VS1 cDNA ORF Clone, Mouse; R16 cDNA ORF Clone, Mouse; RDRC cDNA ORF Clone, Mouse; Slc1a7 cDNA ORF Clone, Mouse

SLC1A5 背景信息

SLC1A5 (solute carrier family 1, member 5), known as ASCT2, is a small neutral amino acid exchanger that is upregulated in rapidly proliferating lymphocytes but also many primary human cancers. SLC1A5 is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts. Solute-linked carrier family A1 member 5 (SLC1A5), which has a high affinity to neutral amino acids, is essential for glutamine transport and amino acid metabolism in various cancers. One of SLC1A5's primary substrates is the immunomodulatory amino acid glutamine, which plays an important role in multiple key processes, such as energy supply, macromolecular synthesis, nucleotide biosynthesis, redox homeostasis, and resistance against oxidative stress. These processes are also essential to immune cells, including neutrophils, macrophages, B, and T lymphocytes.
solute carrier family 1 (neutral amino acid transporter), member 5
  • Scalise M, et al. (2019) Interaction of cholesterol with the human slc1a5 (asct2): Insights into structure/function relationships. Front Mol Biosci 6 110.
  • Scalise M, et al. (2018) The human slc1a5 (asct2) amino acid transporter: From function to structure and role in cell biology. Front Cell Dev Biol 6 96.
  • Masle-Farquhar E, et al. (2017) Asct2 (slc1a5)-deficient mice have normal b-cell development, proliferation, and antibody production. Front Immunol 8 549.
  • Lin J, et al. (2018) Slc1a5 silencing inhibits esophageal cancer growth via cell cycle arrest and apoptosis. Cell Physiol Biochem 48 (1): 397.
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