SLUG cDNA ORF Clone, Mouse, N-HA tag

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SLUG cDNA ORF Clone, Mouse, N-HA tag: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
852 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 208T/C not causing the amino acid variation.
产品特征
Full length Clone DNA of Mouse snail homolog 2 (Drosophila) with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
限制性酶切位点
KpnI + XbaI(6kb+0.85kb)
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

SLUG cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

关于 SLUG的更多信息

Entrez Gene ID

SLUG cDNA ORF Clone, Mouse, N-HA tag: 验证图片

SLUG cDNA ORF Clone, Mouse, N-HA tag: 别称

Slug cDNA ORF Clone, Mouse; Slugh cDNA ORF Clone, Mouse; Snail2 cDNA ORF Clone, Mouse

SLUG 背景信息

SNAI2 is a key regulator of the aggressive phenotype observed in endocrine-resistant breast cancer cells, an independent prognostic biomarker in ER+ advanced breast cancer treated with endocrine therapy, and may be a promising therapeutic target in combination with endocrine therapies in ER+ metastatic breast cancer exhibiting high SNAI2 levels. SNAI2 transformed normal fibroblasts to a CAF-like state and boosted their tumor-supporting role in 3D organotypic culture and in OC xenograft model. SNAI2 drove a transcriptional signature in the mesenchymal subtype of OC that contributed to tumor desmoplasia, which fed back to increase SNAI2 expression and sustain fibroblast activation.
全称
snail family zinc finger 2
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