ST2/IL-1 RL1 cDNA ORF Clone, Mouse, N-Myc tag

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ST2/IL-1 RL1 cDNA ORF Clone, Mouse, N-Myc tag: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
1704 bp
产品特征
Full length Clone DNA of Mouse interleukin 1 receptor-like 1 with N terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ST2/IL-1 RL1 cDNA ORF Clone, Mouse, N-Myc tag: 别称

DER4 cDNA ORF Clone, Mouse; Fit-1 cDNA ORF Clone, Mouse; Ly84 cDNA ORF Clone, Mouse; St2 cDNA ORF Clone, Mouse; St2-rs1 cDNA ORF Clone, Mouse; ST2L cDNA ORF Clone, Mouse; T1 cDNA ORF Clone, Mouse; T1/ST2 cDNA ORF Clone, Mouse

ST2/IL-1 RL1 背景信息

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
全称
interleukin 1 receptor-like 1
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

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