The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
储存 & 运输
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
TAB1 cDNA ORF 核苷酸序列及氨基酸序列信息
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
TGF-β activated kinase-1 binding protein-1 (TAB1) binds and induces autophosphorylation of TGF-beta activating kinase (TAK1). TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. TAB1 forms the protein complex with TAK1 and enhances its kinase activity in the human and mammals. TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. Conventional disruption of the murine Tab1 gene results in late gestational lethality showing intraventricular septum defects and underdeveloped lung alveoli. A single O-GlcNAc site has been identified on human TAB1 that modulates TAK1-mediated cytokine release in cells.
TGF-beta activated kinase 1/MAP3K7 binding protein 1
IL1 signaling pathway
IL17 signaling pathway
Zou Z, et al. (2019) Black carp tab1 up-regulates tak1/irf7/ifn signaling during the antiviral innate immune activation. Fish Shellfish Immunol 89 736-744.
Inagaki M, et al. (2008) Generation of a conditional mutant allele for tab1 in mouse. Genesis 46 (8): 431-439.
Authier F, et al. (2019) A mouse model for functional dissection of tab1 o-glcnacylation. Wellcome Open Res 4 128.