TAB1 cDNA ORF Clone, Mouse, untagged
TAB1 cDNA ORF Clone, Mouse, untagged: 产品信息
基因
种属
Mouse
NCBI 参考序列号
基因长度
1509 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 330T/C,579T/C not causing the amino acid variation.
产品特征
Full length Clone DNA of Mouse TGF-beta activated kinase 1/MAP3K7 binding protein 1.
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
KpnI + XbaI(6.1kb+1.51kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' ) BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.
TAB1 cDNA ORF 核苷酸序列及氨基酸序列信息
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
关于 TAB1的更多信息
Entrez Gene ID
TAB1 cDNA ORF Clone, Mouse, untagged: 验证图片
TAB1 cDNA ORF Clone, Mouse, untagged: 别称
2310012M03Rik cDNA ORF Clone, Mouse; b2b449Clo cDNA ORF Clone, Mouse; Map3k7ip1 cDNA ORF Clone, Mouse
TAB1 背景信息
TGF-β activated kinase-1 binding protein-1 (TAB1) binds and induces autophosphorylation of TGF-beta activating kinase (TAK1). TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. TAB1 forms the protein complex with TAK1 and enhances its kinase activity in the human and mammals. TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. Conventional disruption of the murine Tab1 gene results in late gestational lethality showing intraventricular septum defects and underdeveloped lung alveoli. A single O-GlcNAc site has been identified on human TAB1 that modulates TAK1-mediated cytokine release in cells.
全称
TGF-beta activated kinase 1/MAP3K7 binding protein 1
Related Pathways
-
IL1 signaling pathway -
IL17 signaling pathway
参考文献
- Zou Z, et al. (2019) Black carp tab1 up-regulates tak1/irf7/ifn signaling during the antiviral innate immune activation. Fish Shellfish Immunol 89 736-744.
- Inagaki M, et al. (2008) Generation of a conditional mutant allele for tab1 in mouse. Genesis 46 (8): 431-439.
- Authier F, et al. (2019) A mouse model for functional dissection of tab1 o-glcnacylation. Wellcome Open Res 4 128.
TAB1 cDNA ORF Clone, Human, 相关产品
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