MTFR1 cDNA ORF Clone, Rat, C-HA tag

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MTFR1 cDNA ORF Clone, Rat, C-HA tag: 产品信息

基因
种属
Rat
NCBI 参考序列号
基因长度
1014 bp
产品特征
Full length Clone DNA of Rat mitochondrial fission regulator 1 with C terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MTFR1 背景信息

The Mtfr1 has been confirmed as a targeted gene of miR-324-5p through miRTarBase software and western blot. miR-324-5p protects against oxidative stress-induced EPCs injury by regulating Mtfr1. Knocking down Mtfr1 suppresses mitochondrial fission, apoptosis, and myocardial infarction. Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation. Mtfr1 (mitochondrial fission regulator 1), is a gene involved in the regulation of antioxidant activity in the mouse testis. Mtfr1 protects the male gonads against oxidative stress. Mtfr1/Chppr is a nuclear gene coding for a mitochondrial protein capable of inducing fission of this organelle in a sequence-specific manner.
全称
mitochondrial fission regulator 1
参考文献
  • Wang K, et al. (2015) Nfat4-dependent mir-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting mtfr1. Cell Death Dis 6 (12): e2007.
  • Monticone M, et al. (2007) Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of mtfr1/chppr-deficient mice. Reproduction 134 (3): 483-492.
  • Chen P, et al. (2019) Mir-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting mtfr1. J Cell Physiol 234 (12): 22082-22092.
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